Preparation of AminesAmines
If the migrating group 'R' in the starting amide ( ) is chiral, what is the stereochemical outcome regarding that chiral center in the product amine?
Expert Answer
The reaction proceeds with Retention of Configuration at the chiral center of the migrating group R. The migration step is intramolecular and concerted; the bond from C to R breaks simultaneously as the N to R bond forms, so the stereocenter does not invert.