Preparation of AminesAmines
While acidic or basic hydrolysis can cleave N-alkylphthalimide to release the amine, what reagent is often preferred for milder cleavage, and what is the byproduct?
Expert Answer
Hydrazine ( ) is often preferred (Ing-Manske procedure). It allows cleavage under milder conditions compared to harsh acid/base reflux. The byproduct is Phthalhydrazide, which is often an insoluble solid, facilitating easy separation of the desired soluble amine.