Electrophilic SubstitutionAmines
Why is Acylation preferred over direct Alkylation to prepare mono-substituted amine derivatives?
Expert Answer
Alkylation often leads to poly-substitution (secondary, tertiary, quaternary salts) because the product amine is more nucleophilic than the reactant. Acylation yields a mono-substituted amide because the acyl group is electron-withdrawing and prevents further reaction12.