Identify the pair of reactants that upon reaction, with elimination of HCl will give rise to the dipeptide Gly-Ala.
Biomolecules · Class 12 · JEE Main Previous Year Question
Identify the pair of reactants that upon reaction, with elimination of will give rise to the dipeptide Gly-Ala.
- a✓
Option a
- b
Option b
- c
Option c
- d
Option d
Option a
Step 1: N-terminal and C-terminal — The name Gly-Ala indicates Glycine is at the amino (N) terminus and Alanine is at the carboxyl (C) terminus.
Step 2: Peptide Synthesis — To form the peptide bond (), the carboxyl group of the first amino acid must be activated (e.g., as an acid chloride) to react with the amino group of the second.
Step 3: Identification — Analyzing the reactants, option (a) provides the activated glycine precursor that will react with alanine to form the desired dipeptide.
Key Point: Careful selection of protecting and activating groups is essential in controlled peptide synthesis.
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