JEE Main · 2021 · Shift-ImediumBIO-104

Out of the following, which type of interaction is responsible for the stabilisation of -helix structure of proteins?

Biomolecules · Class 12 · JEE Main Previous Year Question

Question

Out of the following, which type of interaction is responsible for the stabilisation of α\alpha-helix structure of proteins?

Options
  1. a

    Ionic bonding

  2. b

    Hydrogen bonding

  3. c

    Van der Waals forces

  4. d

    Covalent bonding

Correct Answerb

Hydrogen bonding

Detailed Solution

Step 1: Understanding the Alpha-Helix — The α\alpha-helix is a core element of the secondary structure of proteins, characterized by a tightly coiled backbone.

Step 2: Identifying the Stabilizing Force — This helical shape is maintained by intramolecular interactions between the amide groups (NHN-H and C=OC=O) of the peptide chain.

Step 3: Conclusion — Specifically, hydrogen bonding between the C=OC=O of one residue and the NHN-H of the fourth residue down the chain provides the necessary stability. Correct option is (b).

Remember: These hydrogen bonds are approximately parallel to the helical axis.

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