JEE Main · 2023 · Shift-ImediumBIO-081

The one that does not stabilize 2 and 3 structures of proteins is

Biomolecules · Class 12 · JEE Main Previous Year Question

Question

The one that does not stabilize 22^\circ and 33^\circ structures of proteins is

Options
  1. a

    H-bonding

  2. b

    \ceSS\ce{-S-S-}linkage

  3. c

    \ceOO\ce{-O-O-}linkage

  4. d

    van der Waals forces

Correct Answerc

\ceOO\ce{-O-O-}linkage

Detailed Solution

Step 1: Identifying Protein Stabilizers — Secondary (22^\circ) and tertiary (33^\circ) structures of proteins are held together by various non-covalent and covalent interactions.

Step 2: Common Links — Primary among these are hydrogen bonds (α\alpha-helices/β\beta-sheets), disulfide linkages (\ceSS\ce{-S-S-}), and hydrophobic van der Waals forces.

Step 3: Finding the Odd One — Peroxide linkages (\ceOO\ce{-O-O-}) are not involved in biological protein stabilization. Thus, (c) is the correct choice.

Key Point: Disulfide bonds are critical for stabilizing the 3D folding (tertiary structure) of proteins like insulin.

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