Questions/Stereochemistry/If the lowest priori...
Configuration & NomenclatureStereochemistry

If the lowest priority group (4) is on the horizontal line in a Fischer Projection, how is R/S assigned?

Expert Answer

Reverse the result. If 1231 \to 2 \to 3 is Clockwise (normally R), the actual configuration is S because the group is on a wedge (pointing towards you).

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