Questions/Stereochemistry/Is stability always ...
Geometrical IsomerismStereochemistry

Is stability always Trans > Cis?

Expert Answer

No. In medium rings (8-11 carbons), Cis is more stable. In acyclic systems with specific attractive forces (e.g., H-bonding in maleic acid), Cis can be stable, though Trans (fumaric) is generally more stable.

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