The correct structure of the product 'P' in the following reaction is

Question

Canvas Classes · Accepted Answer

Reaction of Asn–Ser dipeptide with excess acetic anhydride:

Asn–Ser structure:

Reactive groups with Ac₂O (NEt₃ as base):

| Group | Reactivity with Ac₂O |
|---|---|
| N-terminus –NH₂ | Acetylated → –NHAc |
| Asn side chain –CONH₂ | Amide N is less reactive; does NOT get acetylated under mild conditions |
| Ser side chain –CH₂OH | Acetylated → –CH₂OAc |
| C-terminus –COOH | Does not react with Ac₂O under these conditions |
| Peptide bond –NH– | Not reactive |

Product P:

- N-terminus acetyla

More questions from Biomolecules