The increasing order of pKa of the following amino acids in aqueous solution is Glycine, Aspartate, Lysine, Arginine.

Question

Canvas Classes · Accepted Answer

pKa values of amino acids (isoelectric points / side chain pKa):

The question asks about pKa of the amino acids (likely referring to the isoelectric point, pI, or the overall acidity/basicity):

| Amino acid | Nature | pI (isoelectric point) |
|---|---|---|
| Aspartate (Asp) | Acidic | ~2.77 (most acidic) |
| Glycine (Gly) | Neutral | ~5.97 |
| Lysine (Lys) | Basic | ~9.74 |
| Arginine (Arg) | Most basic | ~10.76 |

Increasing order of pKa (pI):

Reasoning:
- Aspartate has an extra –COOH side

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