Out of the following, which type of interaction is responsible for the stabilisation of -helix structure of proteins?

Question

Canvas Classes · Accepted Answer

-Helix stabilization:

The -helix is a secondary structure where the polypeptide backbone coils into a right-handed helix. It is stabilized by intramolecular hydrogen bonds:

- The carbonyl oxygen (C=O) of one peptide bond forms an H-bond with the N–H of the peptide bond 4 residues ahead in the sequence
- These H-bonds run approximately parallel to the helix axis
- Each H-bond has energy ~5 kcal/mol; the cumulative effect of many H-bonds makes the helix very stable

Why not others:
- Covalent

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