JEE Main · 2019easyCORD-017

The compound used in the treatment of lead poisoning is:

Coordination Compounds · Class 12 · JEE Main Previous Year Question

Question

The compound used in the treatment of lead poisoning is:

Options
  1. a

    Desferrioxime B

  2. b

    EDTA

  3. c

    Cis-platin

  4. d

    D-penicillamine

Correct Answerb

EDTA

Detailed Solution

🧠 Match Heavy Metal to Antidote

Chelation therapy is a recall question with four classic pairings:

  • Lead (Pb2+\mathrm{Pb^{2+}}) → EDTA (or Ca-EDTA)
  • Copper (Cu2+\mathrm{Cu^{2+}}, Wilson's disease) → D-penicillamine
  • Iron overload → Desferrioxamine B
  • Cancer → Cisplatin

The question asks about lead — answer is EDTA.

🗺️ Pin Down the Choice

(1) Desferrioxamine B — iron chelator, not lead. (2) EDTA — wraps Pb2+\mathrm{Pb^{2+}} in a stable hexadentate cage that the kidneys excrete. ✓ (3) Cisplatin — antitumour drug. (4) D-penicillamine — copper chelator.

The "Six-Arm Hug" Image

EDTA's six donor atoms wrap around Pb2+\mathrm{Pb^{2+}} like a tight hug, locking it into a water-soluble complex that flushes out via urine. That mental image fixes the lead → EDTA pairing for life.

⚠️ Free EDTA Is Dangerous

Clinical detail (often tested at higher levels): pure Na2EDTA\mathrm{Na_2EDTA} would also chelate Ca2+\mathrm{Ca^{2+}} and cause fatal hypocalcaemia. The form actually administered for lead poisoning is calcium-disodium EDTA (CaNa2EDTA\mathrm{CaNa_2EDTA}) — it swaps Ca for Pb in the body. Plain EDTA is the correct textbook answer, but the calcium-buffered form is what reaches the patient.

Answer: (2) EDTA\boxed{\text{Answer: (2) EDTA}}

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